Inhibition of TRPA1 Ameliorates Periodontitis by Reducing Periodontal Ligament Cell Oxidative Stress and Apoptosis via PERK/eIF2α/ATF-4/CHOP Signal Pathway

Figure 5

TRPA1 inhibitor significantly inhibited periodontal tissue destruction and oxidative stress in periodontitis mice. (a) Representative H&E staining and micro-CT images of mouse maxillary (): (1) negative control (healthy group intraperitoneally administered with the same solvent but without HC030031, CON); (2) periodontitis group (experimental periodontitis group intraperitoneally administered with the same solvent but without HC030031, Perio); (3) HC1 group (experimental periodontitis group intraperitoneally administered with 10 mg/kg HC030031, HC1); (4) HC3 group (experimental periodontitis group intraperitoneally administered with 30 mg/kg HC030031, HC3). (b) Detailed schematic diagram of the animal experiment process. (c) Quantitative statistical analysis of alveolar bone loss in micro-CT (). (d) Total SOD and MDAs of mouse serum (). (e, f) Western blot analysis and semiquantitative statistical analysis of mouse gingiva (). ABL: alveolar bone loss. Data analysis was performed by using one-way ANOVA (, , and ). Error bars represent .

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