A Comparison of the Antiosteoporotic Effects of Cornelian Cherry (Cornus mas L.) Extracts from Red and Yellow Fruits Containing Different Constituents of Polyphenols and Iridoids in Osteoblasts and Osteoclasts

Figure 8

The effects of Cornus mas L. extracts on the expression changes of osteoclast-specific genes in the primary osteoclasts of mice. The primary monocytes were incubated with M-CSF (50 ng/mL) and RANKL (50 ng/mL) with or without 10 μg/mL of Cornus mas L. extracts for 5 days. Osteoclast-specific genes including Nfatc1, Ctsk, and Acp5 were measured with qRT-PCR using gene-specific primers. CM; Cornus mas L. extract. vs. induction (Student’s -test).