Laser Capture Microdissection in the Spatial Analysis of Epigenetic Modifications in Skin: A Comprehensive Review

Figure 2

Inverted microscope used in laser microbeam (LMM) and laser capture microdissection (LCM) deploying ultraviolet or infrared laser pulses to target specific tissue sections. The laser-based microdissection is performed in three steps. (a) The laser coupled in the objective separated the desired area from the surrounding tissue. (b) The capture of the marked sample is then initiated using a single laser pulse. (c) The marked sample is then transferred to the desired capture device for downstream analyses. Reproduced under the terms of the Creative Commons CC BY license published by John Wiley and sons. The following original report is credited: von Eggeling and Hoffmann [4].

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