Inhibition of PLK3 Attenuates Tubular Epithelial Cell Apoptosis after Renal Ischemia–Reperfusion Injury by Blocking the ATM/P53-Mediated DNA Damage Response

Figure 1

Bioinformatics analysis of PLK3 expression in renal TECs. (a) The heatmap shows the expression levels of the upregulated and downregulated DEGs (GSE52004). (b) Top 5 upregulated DEGs in TRAP-seq analysis of WT mice. (c) The expression level of PLK3 in four different cell subgroups 24 h after renal I/R injury. (d) The expression level of PLK3 in the TRAP-seq validation dataset (GSE121191) after renal I/R injury. (e) The expression level of PLK3 in single-cell RNA-seq data of normal kidney TECs derived from the Human Protein Atlas (GSE131685). (f) Bubble plots showing the enriched GO terms for PLK3-related biological processes in IRI vs. sham (TRAP-WT) DEGs. (g) Bubble plots showing the enriched GO terms for PLK3-related biological processes in IRI vs. sham (TRAP-Nephron) DEGs. The data are presented as the . . .

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