Inhibition of PLK3 Attenuates Tubular Epithelial Cell Apoptosis after Renal Ischemia–Reperfusion Injury by Blocking the ATM/P53-Mediated DNA Damage Response

<div>PLK3 overexpression reverses the effect of ATM inhibition in alleviating TEC apoptosis. (a) p-ATM protein levels, PLK3 protein levels, and apoptosis-related protein levels were measured by Western blot after the application of KU-60019 and PLK3 plasmid. (b) Flow cytometry was performed to examine the apoptosis of HK-2 cells after the administration of KU-60019 and PLK3 plasmids. (c) TUNEL assays showed the number of apoptotic HK-2 cells. 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Inhibition of PLK3 Attenuates Tubular Epithelial Cell Apoptosis after Renal Ischemia–Reperfusion Injury by Blocking the ATM/P53-Mediated DNA Damage Response 

Figure 7 | Inhibition of PLK3 Attenuates Tubular Epithelial Cell Apoptosis after Renal Ischemia–Reperfusion Injury by Blocking the ATM/P53-Mediated DNA Damage Response 