Alternate-Day Ketogenic Diet Feeding Protects against Heart Failure through Preservation of Ketogenesis in the Liver

Figure 2

Continuous KD feeding impaired the capacity of hepatic ketogenesis in TAC mice. (a) Serum β-OHB concentrations in sham and TAC mice. (b–d) Circulating total cholesterol (TCHO) (b), free fatty acid (FFA) (c), and triglyceride (TG) (d) in sham and TAC mice. (e) Liver weight in sham and TAC mice. (f) Serum alanine aminotransferase (ALT) (f) and aspartate aminotransferase (AST) (g) in sham and TAC mice. (h) H&E and Oil Red staining in liver sections from sham and TAC mice. (i, j) TCHO (i) and TG (j) contents from the liver of sham and TAC mice. (k) KD feeding increased the hepatic β-OHB content in sham mice but not in TAC mice. (l) Contents of CD36, CPT1b, HMGCS2, HMGCL, and BDH1 from the liver of sham and TAC mice. All experiments were conducted at 8 weeks postsurgery. . ; ; .

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)