Investigating the Mechanisms of Jieduquyuziyin Prescription Improves Lupus Nephritis and Fibrosis via FXR in MRL/lpr Mice

Figure 5

Prediction of downstream inflammatory and fibrotic targets of FXR in LN. Combination of the downstream targets of FXR predicted using IPA software (a) with the disease target database of LN and differential genes from transcriptome sequencing to screen for possible downstream inflammatory targets of FXR by upset Venn diagram (b). Wenn plots (c) for screening FXR downstream fibrosis-related targets from GEO database, disease target database, and transcriptome-sequencing data for disease–target intersection analysis; they are presented by the heat map of transcriptome data (d). Box plots (e) showing the differential expression of the focused targets in GEO database. Data are expressed as the deviation (), , .

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