Inhibition of Xanthine Oxidase Protects against Sepsis-Induced Acute Kidney Injury by Ameliorating Renal Hypoxia

Figure 1

Therapeutical effects of febuxostat on attenuating renal injury in SI-AKI mice. (a) Mice pretreated with febuxostat (10 mg/kg/day, po.) for 7 days were administered intraperitoneal injections of LPS (10 mg/kg) and then were executed 24 h after LPS injection. (b) The death of mice in 7 days after intraperitoneal injection of LPS (10 mg/kg). (c–e) Body weight changes and BUN and Scr levels were measured at 24 h after the injection of LPS. (f, g) Histopathology analysis of the kidneys in SI-AKI mice was performed by hematoxylin-eosin (HE) staining (600x magnification), and the kidney tubular injury score was graded in a double-blinded manner.  μm. , , and vs. Ctrl; ^#, ^##, and ^### vs. LPS+Veh (). Ctrl: control; Veh: vehicle; LPS: lipopolysaccharide; Feb: febuxostat; BUN: blood urea nitrogen; Scr: serum creatinine.

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