Identification of Resolvin D1 and Protectin D1 as Potential Therapeutic Agents for Treating Kidney Stones

Figure 1

Identification of significantly reduced DHA-derived lipid mediators of serum in urolithiasis samples. (a) Principal component analysis of lipid mediators using expression data. (b) Lipid mediators are shown in a heat map. Lipid mediators are colour-coded based on the different polyunsaturated fatty acid (PUFA) precursors. (c) Volcano plots showing lipids that were differentially expressed in serum from stone patients and healthy controls. Red/blue dots represent up- or downregulated proteins, respectively, with a FC cut-off of 2 and a value < 0.005. (d) Relative quantitation of DHA and DHA-derived lipid mediators in human serum. AA: arachidonic acid; DHA: docosahexaenoic acid; EPA: eicosapentaenoic acid; LA: linoleic acid.

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