Potential Effects of Nrf2 in Exercise Intervention of Neurotoxicity Caused by Methamphetamine Oxidative Stress

Figure 4

Exercise exerts endogenous antioxidant regulation through the Nrf2 signaling pathway to fight brain oxidative stress injury caused by METH. Exercise has great potential to play an endogenous antioxidant regulatory role through the Nrf2 signaling pathway to decrease harms caused by methamphetamine-induced oxidative stress. However, more experimental evidence is needed to support this idea. Further exploration of the different effects of various parameters of an exercise intervention on Nrf2 signaling pathway intervention (such as exercise mode, time, and intensity) is needed. Whether there is a synergistic effect between exercise and phytonutrient Nrf2 activators is worth further investigation. Created with http://BioRender.com.