Potential Effects of Nrf2 in Exercise Intervention of Neurotoxicity Caused by Methamphetamine Oxidative Stress

Table 2

The role of NRF2 stimulators in the oxidative stress induced by METH.

Stimulator	Species	Research object	Mechanism	Consequence	Ref.
Melatonin	Human	Glioma cell line	Through NF-kappaB and Nrf2 pathways	Protects methamphetamine-induced neuroinflammation	[41]
	Human	Dopamine SH-SY5Y cell lines	Through the NF-κB dependent pathway, upregulates Nrf2 associated with the expression of several antioxidant/detoxification enzymes	Reduces neuronal inflammation	[74]
	Rat	BBB	Promotes the antioxidant process, regulates the expression and translocation of Nrf2	Plays a protective role in the over-upregulation of proinflammatory cytokines and BBB inflammation induced by METH	[75]
Lactulose	Rat	Striatum	Through suppressing oxidative stress and neuroinflammation	Alleviated METH-induced neurotoxicity	[76]
	Rat	Striatum	Alleviating autophagy, stabilizing antioxidant system and suppressing apoptosis	Attenuates METH-induced neurotoxicity	[77]
TBHQ	Rat	VTA	Through the Nrf2/HO-1 and PI3K/AKT signaling pathways	Attenuates neurotoxicity induced by METH	[78]
6,7,4-Trihydroxyflavanone	Human	SH-SY5Y cells	Nrf2/heme oxyganase-1 and PI3K/Akt/mTOR signaling pathways	Mitigates METH-induced neurotoxicity	[79]
Resveratrol	Mice	Hippocampal	Inhibition of oxidative stress and apoptosis	Attenuates methamphetamine-induced memory impairment	[80]