Dopamine D2 Receptor Signaling Attenuates Acinar Cell Necroptosis in Acute Pancreatitis through the Cathepsin B/TFAM/ROS Pathway

Figure 10

Knockdown of TFAM reversed the protective effect of either CA-074Me or quinpirole in vivo. (a) Representative graphs of H&E-stained pancreatic tissue (=6 per group, scale bar 100 μm). (b) Histological scores from caerulein plus LPS-induced pancreatitis (=6 per group). (c) Serum amylase and (d) lipase detected by ELISA (=6 per group). (e) Representative images of DHE-stained pancreas sections showing the levels of superoxide anions (=4 per group, scale bar 100 μm). (f, g) Immunoblot analysis and quantification of RIP3, p-MLKL, and MLKL proteins of pancreas in mice treated with caerulein plus LPS (=4 per group). , , and .

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