Dopamine D2 Receptor Signaling Attenuates Acinar Cell Necroptosis in Acute Pancreatitis through the Cathepsin B/TFAM/ROS Pathway

Figure 9

AAV injection did not cause significant local damage in pancreas. (a) The time axis of AAV injection and drug intervention in caerulein plus LPS-induced pancreatitis. (b) Representative image of GFP stained pancreas 2 weeks after AAV injection. Nuclei were stained with DAPI. (=5 per group, scale bar 200 μm) (c, d) Immunoblot analysis and quantification of TFAM proteins in pancreatitis after AAV-shTFAM infection compared to AAV-Con infection group (=3 per group, scale bar 100 μm). (e) Representative graphs of H&E-stained pancreas showing no histological changes (=5 per group). (f, g) Serum amylase and lipase detected by ELISA (=5 per group). , , and .

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