The ROS/GRK2/HIF-1<i>α</i>/NLRP3 Pathway Mediates Pyroptosis of Fibroblast-Like Synoviocytes and the Regulation of Monomer Derivatives of Paeoniflorin

<div>The levels of hypoxia-inducible factor (HIF)-1<i>α</i> and N-terminal domain of human gasdermin D (GSDMD-N) increase in fibroblast-like synoviocytes (FLS) of RA patients and adjuvant-induced arthritis (AA) rats. (a, b) Immunoblot analysis and quantification of HIF-1<i>α</i> and GSDMD-N in the FLS of RA patients. (c, d) Immunoblot analysis of HIF-1<i>α</i> and GSDMD-N expression levels in FLS of normal, AA, AA+MDP, and AA+MTX rats. 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derivatives of paeoniflorin).</div>

Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: The ROS/GRK2/HIF-1<i>α</i>/NLRP3 Pathway Mediates Pyroptosis of Fibroblast-Like Synoviocytes and the Regulation of Monomer Derivatives of Paeoniflorin 

Figure 3 | The ROS/GRK2/HIF-1α/NLRP3 Pathway Mediates Pyroptosis of Fibroblast-Like Synoviocytes and the Regulation of Monomer Derivatives of Paeoniflorin 