Quantitative Proteomics Reveals the Role of Lysine 2-Hydroxyisobutyrylation Pathway Mediated by Tip60

Figure 2

Characteristics of the Tip60-targeted Khib proteome. (a) Consensus sequence logo plots illustrate a representative sequence of Tip60-targeted Khib sites. (b) Distribution of amounts of Tip60-targeted Khib sites on various enzymes. (c) Abundance distribution of global and Tip60-targeted Khib peptides. (d) Western blot validation of the Khib dynamics on PARK7 in response to Tip60 OE. (e) Abundance distribution of Tip60-targeted Kac and Khib peptides. (f) Overlaps between Tip60-targeted Kac and Khib sites.

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