Quantitative Proteomics Reveals the Role of Lysine 2-Hydroxyisobutyrylation Pathway Mediated by Tip60

Table 1

Tip60-targeted Khib sites on key residues that participate in cofactor/substrate binding, protein interactions, and cancer biomarkers.

Gene name	Site	Function
PKM	207	ATP-binding site
PGK1	220	ATP-binding site
FDPS	123	Isopentenyl diphosphate binding site
HMGCS1	46	Coenzyme A binding site
LRPPRC	1357	RNA-binding site
PLEC	3505	Ovarian cancer biomarker
ADH5	107	Breast cancer biomarker
PARK7	148	Lung cancer biomarker
HSP90AB1	69	Interaction with TP53, BIRC2, NR3C1
LMNA	78	Interaction with MLIP; Spitzoid tumor gene