Protective Effects of Cannabidiol on Chemotherapy-Induced Oral Mucositis via the Nrf2/Keap1/ARE Signaling Pathways

Figure 1

CBD alleviates the severity of chemotherapy-induced OM in mice. (a) Flow diagram of the 5-FU-induced OM model and CBD treatment in mice. (b) Survival curves of mice exposed to drug intervention. (c) Daily body weight loss. (d) Total weight loss on Day 6. (e) Representative images of the ulcer in tongues. (f) Measurements of ulcer sizes. (g) Fecal scores of the mice on Day 4. (h) Coat scores of the mice on Day 4. (i) Representative morphological exhibition of the tongue tissues and epithelium among groups as measured by HE staining. Upper scale bar, 1 mm. Lower scale bar, 50 μm. (j) Epithelial thickness quantification of tongue tissues based on HE staining. Data are expressed as the . ^#vs. vehicle; vs. 5-FU alone group.

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