Research Article
[Retracted] Metformin Ameliorates Senescence of Adipose-Derived Mesenchymal Stem Cells and Attenuates Osteoarthritis Progression via the AMPK-Dependent Autophagy Pathway
Figure 8
Effect of metformin-pretreated ADSCs on cartilage degradation at 12 weeks after DMM surgery. Intra-articular injection of ADSCs was performed biweekly, starting 4 weeks after DMM surgery. (a) The knee joint was harvested at 12 weeks after DMM surgery and analyzed histologically using Safranin O-fast green staining. Scale μm. (b and c) The joint lesions were graded on a scale of 0–6 using the OARSI scoring system. All data are shown as (). Using one-way ANOVA, vs. sham group, #, ##, and ### vs. OA group, and & vs. ADSC group.
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