Isosteviol Sodium Ameliorates Dextran Sodium Sulfate-Induced Chronic Colitis through the Regulation of Metabolic Profiling, Macrophage Polarization, and NF-κB Pathway

Figure 1

Structure of STV-Na and experimental set-up. (a) STV-Na chemical structure. (b) Schematic illustrations of the experimental design for the study. BALB/c mice were fed 2.5% dextran sulfate sodium (DSS) for 63 days in 3 repeated cycles (7-day DSS treatment followed by 14-days of untreated drinking water). STV-Na (10 mg/kg) and 5-ASA (50 mg/kg) were intraperitoneally and orally administered twice daily for 63 consecutive days. IFX (10 mg/kg) was intraperitoneally administered every ten days during the three cycles of DSS treatment. Mice were sacrificed after 63 days for sampling of their spleens and colons.

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