Isosteviol Sodium Ameliorates Dextran Sodium Sulfate-Induced Chronic Colitis through the Regulation of Metabolic Profiling, Macrophage Polarization, and NF-κB Pathway

Figure 3

STV-Na ameliorates DSS-induced chronic colitis. (a) Spleen index. (b) Macroscopic images of colons and (c) colon length. (d) Colon histopathology was examined using H&E staining, and the images were captured at 200x magnification (scale bar, 50 μm). The red arrows represent areas in the intestinal epithelium that are necrotic and denatured in the mucous layer. The black arrows represent crypts that were reduced in depth and inflammatory cell infiltration in the local mucosal layer. The yellow arrows represent inflammatory cell infiltration in the submucosa. (e) Colonic histological score. Data is depicted in terms of . mice per group. An unpaired two-tailed Student’s -test or one-way ANOVA, followed by Tukey’s post hoc analysis, was used to analyze the data. and versus the DSS group.