Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis

Figure 3

Melatonin treatment attenuates the IR-induced renal inflammatory response. (a–c) Melatonin alleviated neutrophil and macrophages recruitment, and then secretion of TNF-α in kidney sections labeled with antibodies against Ly6G, CD68, and TNF-α and score. (d) The mRNA expression levels of IL-1β, TNF-α, MCP-1, and IL-6 in the kidneys was evaluated. Data are presented as the for six mice in each group. compared to the Sham and Sham+MT (20 mg/kg) groups. compared to the IR-treated group. .

(a)

(b)

(c)

(d)