Research Article
Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis
Figure 5
Melatonin reduces IR-induced ferroptosis in the AKI mouse model. (a) The fluorescent probe DHE (red) indicating ROS in kidneys sections from IR-induced mice. (b, e) Lipid peroxidation levels were measured by 4-HNE and MDA in kidney tissue. (c, d) SOD and GSH-Px levels in kidney tissue after IR-AKI. (f) Fe2+ concentration in kidney tissue after IR-AKI. Data are presented as the for six mice in each group. compared to the Sham and Sham+MT (20 mg/g) groups. compared to the IR-treated group. .
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