Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis

Figure 9

Melatonin prevents FA-induced acute kidney injury in mice. (a) Serum ALT. (b–d) BUN, serum creatinine (Scr), and Ccr level; the result shows that MT or Fer-1 could alleviate the kidney injury in FA-AKI. (e–h) Representative image of HE and PAS and tubular damage was scored semiquantitatively. (i) Real-time PCR of KIM-1 and IL-1β expression in FA-AKI model. Data represent the for 6 mice in each group. compared with the NC and NC+MT (20 mg/kg) groups. compared with the folic acid- (FA-) treated group. .

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