Flavonoids Targeting the mTOR Signaling Cascades in Cancer: A Potential Crosstalk in Anti-Breast Cancer Therapy

Figure 3

Depiction of mechanistic approaches involved in chemoresistance during breast cancer. Abbreviations: EGFR: epidermal growth factor receptor; IL-6: interleukin–6; TNF-α: tissue necrosis factor–alpha; STAT3: signal transducer and activators of transcription 3; JAK2: Janus kinase 2 gene; PI3K: phosphatidylinositol–3–kinase; mTOR: mammalian target of rapamycin; Akt: serine/threonine–protein kinase; PTEN: phosphatase and tensin homolog.