|
Methods or compounds | Time | Effect on mitophagy | Doses | Action site | Function in TBI | Reference |
|
Resolvin D1 | 2020 | Activate | 15 μg/kg | Inflammation | Ameliorate brain oedema and cognitive impairment, suppress neuroinflammation and neuronal loss,eliminate extra mitoROS, improve the supportive function of astrocytes | [29] |
IL-10 | 2019 | Activate | Overexpress | Inflammation | Inhibit inflammatory response, reduce neuronal degeneration and death | [53] |
Pifithrin-μ Pifithrin-α | 2019 | Mitigate | 2 mg/kg | Inflammation | Ameliorate neurological functional deficits, attenuate neuroinflammation, attenuate oxidative stress | [54] |
Rapamycin | 2019 | Activate | 3 mg/kg | Inflammation Cell death | Attenuate neuroinflammation, mitochondrial damage, demonstrate neuroprotective effects, inhibit the activation of NLRP3 inflammasome | [55] |
Melatonin | 2016 | Activate | 5 ml/kg | Inflammation | Repress inflammation, ameliorate neuronal death and behavioral deficits, dampen the secretion of pro-inflammatory cytokines | [56] |
Rapamycin | 2016 | Activate | / | Oxidative stress | Alleviate TBI-induced intestinal mucosa damage and epithelial barrier dysfunction | [60] |
Mdivi-1 | 2017 | Suppress | 3 mg/kg | Oxidative stress Cell death | Alleviate loss of mitochondrial membrane potential, ROS production, ATP reduction, blood-brain barrier disruption and cell death | [27] |
Mdivi-1 | 2018 | Suppress | 1 mg/kg | Oxidative stress Cell death | Aggravate neurological manifestations and neuronal apoptosis | [64] |
DCTEIO | 2020 | Activate | 40 mM aqueous solutions | Oxidative stress | Scavenge ROS, improve tissue repair and preserve neurological function | [66] |
Triiodothyronine | 2020 | Activate | 20 μg/100 g | Oxidative stress Cell death | Reduce ROS production, prevent neuronal death, induce neurogenesis and neuroprotection | [30] |
Cardiolipin siRNA | 2019 | Activate | 30 nmol | Cell death | Induce endogenous neuroprotection, limit neuronal apoptosis and behavioral deficits | [11] |
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