Cancer Cell Membrane Biomimetic Mesoporous Nanozyme System with Efficient ROS Generation for Antitumor Chemoresistance

Figure 2

(a) TEM image of Fe SAZs. (b) TEM image of CSD. (c) High magnification TEM image of CSD. (d) Absorption spectra of Fe SAZs, DDP, and CSD in PBS. (e) Statistical graph of measured diameter size of Fe SAZs and CSD (). (f) Zeta potential values for Fe SAZs, CV, and CSD nanovesicles (). (g) Under different H₂O₂ conditions, the absorption peak at 652 nm in the chromogenic reaction of TMB involving Fe SAZs and CSD (; 1: Fe SAZs, 1 mM H₂O₂; 2: CSD, 1 mM H₂O₂; 3: Fe SAZs, 2 mM H₂O₂; 4: CSD, 2 mM H₂O₂; 5: Fe SAZs, 5 mM H₂O₂; and 6: CSD, 5 mM H₂O₂). (h) Under different pH conditions, the absorption peak at 652 nm in the chromogenic reaction of TMB involving Fe SAZs and CSD (; 1: Fe SAZs, ; 2: CSD, ; 3: Fe SAZs, ; 4: CSD, ; 5: Fe SAZs, ; and 6: CSD, ). (i) In vitro DDP release profile in the presence and absence of H₂O₂ ().

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