The Imbalance of Mitochondrial Homeostasis of Peripheral Blood-Derived Macrophages Mediated by MAFLD May Impair the Walking Ability of Elderly Patients with Osteopenia

Figure 1

Potential ways of interaction between NAFLD and osteopenia. (a) Venn diagram of the overlap genes between 1058 NAFLD-related genes and 845 osteopenia-related genes from DisGeNET. (b) The hub gene was determined by the construction of PPI network. (c) Top 18 KEGG enrichment pathways of 261overlap genes. (d) The levels of IL-6 and IL-8 in plasma of the patients from SO, OPe, and OPe with MAFLD group were determined by ELISA. Bars, means SE; , , , . Abbreviations: NAFLD: nonalcoholic fatty liver disease; PPI: protein-protein interaction; KEGG: Kyoto Encyclopedia of Genes and Genomes; ELISA: enzyme-linked immunosorbent assay; IL-6: interleukin-6; SO: severe osteoporosis; OPe: osteopenia; MAFLD: metabolic dysfunction-associated fatty liver disease.

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