The Imbalance of Mitochondrial Homeostasis of Peripheral Blood-Derived Macrophages Mediated by MAFLD May Impair the Walking Ability of Elderly Patients with Osteopenia

Figure 2

NAFLD and osteopenia may interact through immune pathways. (a) Top 10 GO enrichment items of DEGs between OPe and SO patients from Array Express. (b) Venn diagram of the overlap between immune-related genes and DEGs. (c) The heat map shows the expression of the overlap genes of bone biopsy between OPe and SO patients. (d and e) GO enrichment analysis and KEGG pathway analysis of these 81 overlap genes. (f) Venn plot indicated the overlap between NAFLD-related genes and DEGs. DEGs are derived from the monocytes samples of low and high BMD subjects in GEO database. (g) The heat map indicates the expression level of genes between low and high BMD samples. Abbreviations: SO: severe osteoporosis; OPe: osteopenia; DEG: differentially expressed genes; GO: Gene Oncology; DEGs: differentially expressed genes; KEGG: Kyoto Encyclopedia of Genes and Genomes; BMD: Bone Mineral Density; NAFLD: nonalcoholic fatty liver disease.

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