Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2<i>α</i>-ATF4 Axis

<div>Daurisoline inhibited the viability of ESCC cells. (a) The chemical structure of DAS. (b) Human ESCC cell lines EC1 and ECA109 were treated with indicated concentrations of DAS for 72 hours, and the IC<sub>50</sub> was determined by CCK-8 assay. (c) EC1 and ECA109 cell lines were treated with indicated concentrations of DAS for 24 and 48 hours. (d) Representative images of three independent experiments were shown for the inhibition of colony formation by DAS and a statistical graph of the relative number of colonies formed.</div>

Oxidative Medicine and Cellular Longevity

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Figure 1

Figure 1: Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2<i>α</i>-ATF4 Axis 

Figure 1 | Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2α-ATF4 Axis 