Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2<i>α</i>-ATF4 Axis

<div>Daurisoline suppressed the growth of ESSC <i>in vivo</i>. (a) Nude mice were subcutaneously transplanted with ECA109 cells and treated with DAS as indicated in materials and methods. Tumor size was determined with a caliper every day, and the volume was calculated to construct a growth curve. (b) The tumor weight was measured with an electronic scale. (c) Mice were sacrificed, and tumor tissues were harvested and photographed. (d) IHC staining for Ki-67 in tumor sections. (e) A statistical graph of the Ki-67 average staining score of the PEG300 control group and DAS (40 mg/kg) treatment group. (f) Tissue proteins were extracted and detected by western blot.</div>

Oxidative Medicine and Cellular Longevity

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Figure 8

Figure 8: Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2<i>α</i>-ATF4 Axis 

Figure 8 | Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2α-ATF4 Axis 