Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2<i>α</i>-ATF4 Axis

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">siRNA</td><td class="align_center">Sequence (5<span class="nowrap"><svg height="7.86364pt" id="M6" style="vertical-align:-0.04981995pt" version="1.1" viewbox="-0.0498162 -7.81382 4.53621 7.86364" width="4.53621pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M295 534L291 558C277 573 202 603 180 597L75 72L120 51L295 534Z"></path></g></svg>-</span>3<span class="nowrap"><svg height="7.86364pt" id="M7" style="vertical-align:-0.04981995pt" version="1.1" viewbox="-0.0498162 -7.81382 4.53621 7.86364" width="4.53621pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M295 534L291 558C277 573 202 603 180 597L75 72L120 51L295 534Z"></path></g></svg>)</span></td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">Si-control</td><td class="align_center">UUCUCCGAACGUGUCACGU</td></tr><tr><td class="align_left">Si-p21#1</td><td class="align_center">GACCAUGUGGACCUGUCAC</td></tr><tr><td class="align_left">Si-p21#2</td><td class="align_center">AAUGGCGGGCUGCAUCCAGGA</td></tr><tr><td class="align_left">Si-p27#1</td><td class="align_center">CCGACGAUUCUUCUACUCA</td></tr><tr><td class="align_left">Si-p27#2</td><td class="align_center">CCGACGAUUCUUCUACUCA</td></tr><tr><td class="align_left">Si-Noxa#1</td><td class="align_center">GGUGCACGUUUCAUCAAUUUG</td></tr><tr><td class="align_left">Si-Noxa#2</td><td class="align_center">CCGGCAGAAACUUCUGAAU</td></tr><tr><td class="align_left">Si-DR5#1</td><td class="align_center">AAGACCCUUGUGCUCGUUGUC</td></tr><tr><td class="align_left">Si-DR5#2</td><td class="align_center">CAGCCGUAGUCUUGAUUGU</td></tr><tr><td class="align_left">Si-CHOP</td><td class="align_center">GCCUGGUAUGAGGACCUGC</td></tr><tr><td class="align_left">Si-ATF4#1</td><td class="align_center">CCUCACUGGCGAGUGUAAA</td></tr><tr><td class="align_left">Si-ATF4#2</td><td class="align_center">GCCUAGGUCUCUUAGAUGA</td></tr><tr><td class="align_left">Si-eIF2<i>α</i>#1</td><td class="align_center">CGUAUCCGUUCUAUCAACAAACUCA</td></tr><tr><td class="align_left">Si-eIF2<i>α</i>#2</td><td class="align_center">AGCAGAUAUUGAAGUGGCUUGUUAU</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>siRNA sequences for target genes.</div>

Oxidative Medicine and Cellular Longevity

tab2

Table 2

Table 2: Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2<i>α</i>-ATF4 Axis 

Table 2 | Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2α-ATF4 Axis 