Superoxide Dismutase Prevents SARS-CoV-2-Induced Plasma Cell Apoptosis and Stabilizes Specific Antibody Induction

Figure 5

CoV exposure activates the JAK2/STAT1 signal pathway in sPCs. sPCs were prepared and exposed to CoV in the culture at 10 μg/ml overnight. (a, b) Protein extracts of sPCs were analyzed by Western blotting. Immunoblots show phosphor JAK2 and STAT1. (c) co-IP results show a complex of pSTAT1/SOD in sPC protein extracts. (d) Ubiquitin was colocalized at the SOD plots in (c) (by reblotting on the same membrane). The data are from one experiment that represents 6 independent experiments.