Protective Effect and Possible Mechanisms of Artemisinin and Its Derivatives for Diabetic Nephropathy: A Systematic Review and Meta-Analysis in Animal Models

Table 3

Results from Egger’s test and trim and fill analysis on BUN and SCr.

Outcomes	Egger’s value	Before trim and fill			After trim and fill
		value	Total effect sizes [95% CI]	No. studies	value	Total effect sizes [95% CI]	No. studies
BUN	0.002	<0.00001	-3.71 [-4.98, -2.45]	11	0.005	-1.984 [-3.369, -0.599]	16
SCr	0.002	<0.00001	-2.70 [-3.50, -1.89]	11	<0.0001	-1.924 [-2.808,-1.047]	16

Abbreviations: BUN: blood urea nitrogen; CI: confidence interval; SCr: serum creatinine.