Orcinol Glucoside Improves Senile Osteoporosis through Attenuating Oxidative Stress and Autophagy of Osteoclast via Activating Nrf2/Keap1 and mTOR Signaling Pathway

Figure 7

OG suppresses autophagy by activating mTOR signaling in bone tissue of SAMP6 mice and osteoclast derived from RAW264.7 cells. (a) Representative Western blot images and the quantification of p-mTOR, mTOR, p-p70S6K, and p70S6K expression in bone tissue of SAMP6 mice. (b) Representative Western blot images and the quantification of p-mTOR, mTOR, p-p70S6K, and p70S6K expression in the osteoclast with the treatment of OG or RAP incubation for 48 h. Each point represents (). , vs. the indicated group.

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