Curcumin Enhanced Ionizing Radiation-Induced Immunogenic Cell Death in Glioma Cells through Endoplasmic Reticulum Stress Signaling Pathways

Figure 1

Curcumin enhanced apoptosis induced by IR in normoxic and hypoxic glioma cells. (a) The survival rates of GL261 and U251 cells after treatment with various concentrations of curcumin for 24 h. (b) Under normoxic conditions, GL261 and U251 cells were treated with 10 and 30 μM curcumin and incubated for 24 h after 10 Gy IR. Cell apoptosis was detected by flow cytometry after 7AAD/PE staining. (c) Under hypoxic conditions, GL261 and U251 cells were treated with/without 30 μM curcumin and incubated for 24 h after 10 Gy/25Gy IR. Cell apoptosis was assessed by flow cytometry after 7AAD/PE staining. , , and vs. control; ^# and ^### vs. IR.

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