Curcumin Enhanced Ionizing Radiation-Induced Immunogenic Cell Death in Glioma Cells through Endoplasmic Reticulum Stress Signaling Pathways

Figure 5

Curcumin enhanced IR-induced glioma ICD in vivo. (a) The schematic diagram and schedules of vaccination experiment. Tumors formed subcutaneously in mice 30 days after inoculation were shown in red circles. (b) Mice were subcutaneously injected with and glioma cells treated with 30 μM curcumin, 10 Gy X-ray, and both, respectively, and the control group was injected with PBS. One week later, tumor cells were injected into the contralateral side, and the tumor size was measured every 3 days. Each line represents a tumor-forming mouse. (c) Kaplan-Meier curves for the percentage of tumor free mice after inoculation with live tumor cells. All treatments significantly delayed or rejected tumor growth compared to control. , , and vs. control; ^#, and ^## vs. IR. (d) Tumor photos 30 days after inoculation.

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