Oxidative Medicine and Cellular Longevity

Review Article

A Common Feature of Pesticides: Oxidative Stress—The Role of Oxidative Stress in Pesticide-Induced Toxicity

Table 1

The effects of the most commonly used pesticides in the agricultural market sector in 2012 on oxidative stress in different tissues.
PesticideCell type/model systemROSSODGSHCATGSTGPxDDLPPCAOCMMPReference
GlyphosateHuman skin keratinocyte HaCaT cells↑↓[178]
Human liver carcinoma (HepG2) cells↓↑↓[179]
Rat heart H9c2 cells↓[180]
Adult albino male rats (liver)↓↑[181]
Caenorhabditis elegans↑↓[182]
Chlorella kessleri↑↑↑↑[183]
Atrazine (ATR)Male and female Balb/c mice↑↓[184]
Male mice (liver and kidney)↓↓↓↑↓[185]
Male Wistar rats (erythrocytes)↑↓↑↑↑[155]
Adult male Wistar rats (testes and epididymis)↓↓↓↑[186]
Male Wistar rats↓↓↓↑[187]
Adult male albino rats↓↓↓↓↑[188]
Female Wistar rats↓↓↑[189]
Murine microglial cells (BV-2)↑[190]
Albino rats↓↑↑↑↑[191]
Metolachlor-SScenedesmus obliquus (green algae)↑↑↑[192]
Parachlorella kessleri (microalga)↑↑↑[193]
Wheat (Triticum aestivum L.)↑↑↓↑[194]
2,4-Dichlorophenoxyacetic acid (2,4-D)Umbelopsis isabelline (Fungus) pea (Pisum sativum L.)↑↑↑↑[195, 196]
Pea (Pisum sativum L.)↑↑↑↑[196]
Nongreen potato tuber callus↑↑↑[197]
Male 7-week-old Kunming mice↓↓↑[198]
Goldfish gills, Carassius auratus↑↑↑↑↑[199]
Cnesterodon decemmaculatus↑↑↑↑[200]
Acanthospermum hispidum D.C., Asteraceae weed↑[201]
Rat cerebellar granule cells↑↓↓↑[202]
Wistar rats↓↓↓↓↑[203]
Wistar Albino rats↓↓↓↓↓↑↑[204]
Male Wistar rats (liver)↑↓↓↓↑[205]
Male Wistar albino rats—plasma, liver, kidney, erythrocytes↓↓↓↑[206]
Male Wistar rats (liver)↓[207]
Female B6C3F1 mice peritoneal macrophages↓[208]
MetamSoil bacteria↑↓↑[209]
AcetochlorBufo raddei tadpole liver↑↑↓[210]
Female zebrafish↑↑↑↑[211]
Male C57BL/6 mice (testis)↓↓↑[212]
GC-1 spermatogonia cell↓↓↑[212]
Human liver carcinoma cells (HepG2)↑↓↓↓[213]
Zebrafish↑↑[214]
Primary human corneal epithelial (HCE) cells↑↑↑[215]
ChloropicrinHuman retinal pigment epithelial cells (ARPE-19)↑[216]
Human lung epithelial cells (A549)↑[217]
Gill tissues of Pacific oyster (Crassostrea gigas), blue mussels (Mytilus edulis)↑↑↑↑↑[218]
ChlorothalonilPolychaete Laeonereis acuta↑↓[219]
Fish Danio rerio (gills)↑↑↑[220]
Fish Danio rerio (liver)↑↑[220]
Isolated rat hepatocytes↓↑[221]
Botryllus schlosseri hemocytes↓[222]
Male Wistar rats (liver)↑[223]
Fresh water fish, Channa punctatus↓↓↓↑[224]
PendimethalinMale Wistar rats (liver and kidney)↓↓↓↓↑↑↑[225]
Human lymphocytes↑↑[226]
Rat bone marrow cells↑↓↓↑↑[226]
Clarias batrachus (liver)↑↑↑[227]
Fish Channa punctatus (brain)↓↓↓↓↑↑[228]
Fish Channa punctatus (gills, liver, kidney)↓↓↓↓↑↑[229]
Chinese hamster lung fibroblast (V79) cells↑↑[230]
Male mice (spleen and thymus)↔↓↓↓↑[145]
Ethephon3T3 murine embryonic fibroblast (MEF) cells↑↑↑[231]
Spinach (Spinacia oleracea L.)↑[232]
Ipomoea cairica (Linn.) sweet↑[233]
Carassius auratus goldfish blood and gills↑↑↑↑↑[234]
MancozebCarassius auratus Goldfish—liver and kidney↑↑↑↑↑[235]
Carassius auratus Goldfish—brain↑↑[235]
Cassia angustifolia↑↑↑↑[236]
Caenorhabditis elegans↑↑↓[237]
Caenorhabditis elegans↑↑↓[238]
Drosophila melanogaster↑↓↓↑↑↑[239]
Rat-1 fibroblasts, peripheral blood mononucleated cells (PBMC)↑↑[240]
Male NMRI mice↓↓↓↓↑↑↓[241]
Rat thymocytes↑↓[242]
Human gastric adenocarcinoma (AGS) cells↑↓[243]
Immortalized murine mesencephalic dopaminergic (N27) cells↑↓↑↓[80]
ChlorpyrifosLund human mesencephalic (LUHMES) cells↑↑↓[80]
Human neuroblastoma SH-SY5Y cells↑[244]
Rat adrenal pheochromocytoma (PC12) cells↑↑[245]
Rat erythrocytes↓↓↓↑[156]
Male Wistar rats↓↓↑↑[63]
Male Wistar rats (aorta, liver, plasma, and kidney)↑↑[246]
Male Swiss albino adult rats↓↓↓↓↑[247]
Adult male Wistar rats↑[248]
Male Wistar rats↑↑↓↓↑[249]
Male Kunming mice↑↓↓↓↓↑[250]
Male Wistar rats (liver)↓[251]
MetolachlorSoil bacteria↓↑↑[209]
Lettuce, bean, and pea seeds and leaves↓↓↓[252]
8-week-old male rats↓↓↓↓↑[253]
PropanilWistar rats, liver↓↓↓↓↑[151]
Albino rats, liver↓↓↑[254]
Common carp (Cyprinus carpio) brain↓↓↓↑↑[255]
Isolated mitochondria from potato tubers (Solanum tuberosum)↓[256]
DicambaNongreen potato tuber callus↑↑↑[197]
Cnesterodon decemmaculatus↑↑↑↑[200]
Isolated mitochondria Arabidopsis↑[257]
Chinese hamster lung fibroblast (V79) cells↑↑[230]
TrifluralinMale Wistar albino rats—kidney, ureter, urinary bladder↓↓↑↑[258]
Chlamydomonas mexicana↑↑[259]
AcephateDrosophila melanogaster↑↑↑↑↑↑[260]
Male albino rats (plasma and liver)↓↓↓↑↑[261]
Male rats (erythrocytes)↓↑↑[262]
Albino rats↓↓↓↑[263]
Human sperm↑[264]
Chinese hamster ovary (CHO-K1) cells↑↑↑[265]
Porcine kidney proximal tubule cell line (LLC-PK)↑↑[266]
Human dopaminergic neuroblastoma cells (SK-N-SH)↑↑↓[267]
Paraquat (PQ)Rat lung slices↑[268]
Rat organotypic midbrain slice cultures↑[269]
Rat primary mesencephalic cultures↑[270]
Rat primary mesencephalic cultures↑[79]
Human neural progenitor cells (hNPCs)↓↓↑[135]
Human neural progenitor cells (hNPCs)↑[271]
Human plasma↑↓[51]
Rat brain mitochondria↑[79]
Nongreen potato tuber callus↑↑[197]
Amaranthus palmeri↑↑↑[272]
GlufosinateHorseweed, palmer amaranth, kochia↑↑↑↑[273]
Chlorella vulgaris↑↑↑[274]
ROS: reactive oxygen species; SOD: superoxide dismutase; GSH: glutathione; CAT: catalase; GST: glutathione-S-transferase; GPx: glutathione peroxidase; DD: DNA damage; LP: lipid peroxidation; PC: protein carbonylation; AOC: antioxidant capacity; MMP: mitochondrial membrane potential; ↑: increased; ↓: decreased.