Emodin Attenuates the ECM Degradation and Oxidative Stress of Chondrocytes through the Nrf2/NQO1/HO-1 Pathway to Ameliorate Rat Osteoarthritis

Figure 1

Establishment of rat posttraumatic OA model and in vivo experiment design. (a) Rats were anesthetized by inhalation of 2% isoflurane in oxygen/nitrous oxide. (b) Depilation and disinfection of the right knee joint of the rat. (c) Make a longitudinal 2-3 cm incision on the inside with a scalpel. (d) After the patella is displaced, the ACL is cut under a surgical microscope. (e) Under sterile conditions, use absorbable slits to suture the wound. (f) The flow chart of the in vivo study design, showing the time of administration of emodin, the treatment period, and the time of euthanasia.

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