Rosiglitazone Ameliorates Spinal Cord Injury via Inhibiting Mitophagy and Inflammation of Neural Stem Cells

Figure 7

Graphic abstract. The present study showed that the inhibitions of FOXO1 and PINK1 were critically involved in the mechanisms of rosiglitazone-induced mitophagy suppression, which greatly contributed to the enhanced glycolysis and proliferations of NSCs. Besides, we identified that the reduced FOXO1 level, which directly binded to the transcriptional regulation region in PINK1 gene, is the main underlying mechanisms for the decreased PINK1 and mitophagy.