Renal and Inflammatory Proteins as Biomarkers of Diabetic Kidney Disease and Lupus Nephritis

Table 3

Sensitivity and specificity.

(a)

Control vs. DKD
Biomarker	Cut-off point (pg/ml)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Likelihood ratio	Accuracy (%)
ASC	>632	89	63	61	90	2.400	73
IL-18	>268.7	74	53	53	74	1.595	62
CRP	> 2,984,567	61	51	42	69	1.249	55
uPA	> 875	70	57	58	68	1.610	63
EGF	> 27.99	100	94	95	100	17.00	97
Lipocalin-2	> 10,187	100	83	78	100	6.00	89

(b)

Control vs. LN
Biomarker	Cut-off point (pg/ml)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Likelihood ratio	Accuracy (%)
ASC	> 521.6	63	53	50	66	1.344	57
IL-18	> 278.9	78	58	58	78	1.866	67
CRP	> 3,768,714	66	62	56	71	1.703	63
uPA	> 890.3	84	65	72	79	2.415	75
EGF	> 38.53	100	100	100	100	—	100
Lipocalin-2	> 10,516	88	83	79	91	5.294	85