Catalpol Enhances Random-Pattern Skin Flap Survival by Activating SIRT1-Mediated Enhancement of Autophagy

<div>CAT improves autophagy in in random skin flaps. (a) Flap tissue sections were stained with anti-LC3II (green) immunofluorescence antibodies (DAPI staining of the nuclei). Scale bar: 10 <i>μ</i>m. (b) Quantification of percentage of LC3II positive cells in the dermal layer. (c, d) IHC and quantification analysis of CTSD in the control and CAT group. (e, f) Western blotting for expression of Belin1, LC3II, CTSD, and p62. GAPDH was used as a loading control. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Catalpol Enhances Random-Pattern Skin Flap Survival by Activating SIRT1-Mediated Enhancement of Autophagy 