Catalpol Enhances Random-Pattern Skin Flap Survival by Activating SIRT1-Mediated Enhancement of Autophagy

Figure 8

Schematic model of CAT promotes random flap survival via SIRT1-dependent autophagy mechanism. CAT increased SIRT1 expression. Overexpression of SIRT1-activated AMPL/mTOR pathway enhances autophagy to increase flap survival by increasing angiogenesis, inhibiting oxidative stress, and suppressing apoptosis.