Metabolomic Identification of Serum Exosome-Derived Biomarkers for Bipolar Disorder

Figure 1

Identification of differentially expressed serum exosomal metabolites in bipolar disorder (BD). (a) Principal components analysis (PCA) and (b) an orthogonal partial least squares discriminant analysis (OPLS-DA) model diagram according to the blood exosomal metabolites in the BD patients and healthy control (HC) subjects. (c) Heatmaps showing differentially expressed blood exosomal metabolites in patients with BD as compared to HC subjects. (d) Illustration of the 26 differentially expressed metabolites in BD. (e) KEGG enrichment pathways for the 26 serum exosomal metabolites differentially expressed in BD.

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