Delving the Role of Caralluma fimbriata: An Edible Wild Plant to Mitigate the Biomarkers of Metabolic Syndrome

Table 5

Various studies of C. fimbriata’s therapeutic potential against MS.

Main component	Study subject	Material and method	Result	References
CFE	Overweight adults	Daily supplementation (16 weeks)	A significant effect on body weight maintenance was observed	[20]
CFE	Adults (97)	500 mg for 8 weeks	Significant reduction in stress and anxiety	[28]
CFE	A 14-year-old female (PWS)	CFE supplementation over 12 years	Significant effect against hyperphagia and obesity	[32]
Hydroalcoholic extract of C. fimbriata	Animal model (40 rats)	HFD-induced cardiac damage was analyzed	Cardiac protective outcomes were observed	[62]
C. fimbriata	Human colon cancer cells	MTT cell viability assay was performed on KB cell lines	Good antiproliferative activity against KB mouth cell line	[88]
Hydroalcoholic extract of C. fimbriata	Animal model (Wister rats)	Oxidative stress markers GSH, LO, PO, SDH, and AR were examined	Reduced oxidative and pancreatic damage caused by HFD	[89]
Hydroalcoholic extract of C. fimbriata	Animal model (HFD diabetic rats)	Carbohydrate metabolism was analyzed in rats with HFD	Significantly restore the levels of glycogen in the liver and muscles	[18]
Ethanolic leaf extract of C. fimbriata	Human colon cancer cell	Antiproliferative effects were evaluated using MTT assays	Reduced cell proliferation by inducing cytotoxicity of COLO 320 cells	[88]
Commercially available CFE	Animal model (female rats)	Modulation of brain neuropeptides NPY and ORX	Significant reduction in weight gain	[55]
Ethanolic leaf extract of C. fimbriata	Vitro approach	Alpha-amylase and alpha-glucosidase inhibitory assay with acarbose as control	Potent antihyperglycemic activity	[23]
Hydroalcoholic extract of C. fimbriata	Animal model (male Wister rats)	Renal functional and oxidative stress markers were checked	Effectively alleviated the HFD-induced renal damage	[35]
CFE and metformin	Wister rats	Lipid profile was analyzed	Significant reduction in lipid profile	[39]
CFE	Male Wister rats	Oxidative stress markers were checked	Significant protection against HF diet	[34]
CFE	Animal and human	Snord116 deletion	Significant alteration in appetite	[90]
CFE	PWS children and adolescents	Appetite behavior was recorded	Significant reduction in hyperphagia	[30]
CFE	Overweight and obese individuals	Anthropometry, appetite, and biochemical investigation done	No significant changes in the biochemical and clinical parameters	[91]
CFE	Animal model	Glucose, leptin, and triglycerides were measured	Significant reduction in insulin resistance and oxidative stress	[14]
CFE	Animal model	Metabolic parameters were assessed	Significant reduction in food intake and blood pressure	[92]
CFE	Animal model	Hepatotoxic, diabetic, and renal toxicities were analyzed	Significant reduction in diabetes	[87]
CFE	Animal model	Renal and liver function tests were measured	Significant reduction in body weight and lipid profile	[93]
CFE	Animal model	Serum lipid profile and blood glucose were measured	Significant alteration in lipid profile and body weight	[94]
CFE	Overweight and obese individuals	500 mg capsules twice for 12 weeks	CFE showed a reduction in BMI, weight gain, hip circumference, and systolic blood pressure	[95]