Perinatal Hyperoxia and Developmental Consequences on the Lung-Brain Axis

Table 1

Experimental models of hyperoxia-induced brain and lung injury.

	O2 concentration (%)	HO onset	HO duration	Species	Reference
Brain	40-80	P7	2 h–3 d	Wistar rats/ synRAS mice and wt mice	[43]
	80	Birth	6 d	Sprague-Dawley rats	[44]
	80	P1	7 d	Sprague-Dawley rats	[69]
	80	P3	48 h	Wistar rats	[50]
	80	P3, P6, P10	24 h	Wistar rats	[75]
	80	P6	2 h–48 h	Wistar rats	[53, 73, 101]
	80	P6	2 h–48 h	C57BL/6^IRAK-4[-/-] and C57BL/6 mice	[53]
	80	P6	12 h, 48 h	Wistar rats	[72]
	80	P6	24 h	Wistar rats	[49, 54, 74, 108, 134–136, 152, 179]
	80	P6	24 h	SynRas mice and C57BL/6	[57]
	80	P6	6 h–48 h	Wistar rats	[52]
	80	P6	24 h, 48 h	Wistar rats	[51]
	80	P6	48 h	C57B/6J mice	[55, 56]
	≥80	P7	24 h	Wistar rats	[98]
	85	P2	12 d	C57BL/6 mice	[70]
	95	P0	7 d	C57BL/6 mice and C57BL/6^(hEC-SOD) mice	[71]
	>95	P5	7 d	Sprague-Dawley rats	[42]
	100	P0	4 d	C57BL/6J mice and Sftpc^(EC−SOD) mice	[68]
Lung	60	P1	14 d	Sprague-Dawley rats	[180]
	65	P3	4 weeks	C57BL/6J mice	[91]
	70	P0	14 d	C57BL/6J mice (male)	[62]
	75	P1	7 d	FVB mice	[165]
	80	P0	3 d, 5 d	Wistar rats	[59, 102]
	80	P1	10 d	C57BL/6J mice	[99]
	80	P6	6 h-48 h	Wistar rats	[100]
	40-80	P0	3 d–28 d	C57BL/6 mice and B6.129S2-IL6^(tmlKopf/j)	[60]
	40-85	P1, P4	24 h–14 d	C57BL/6 mice	[76]
	85	P0	14 d	C57BL/6J mice	[61]
	85	P1	14 d	C57BL/6J, BALB/cJ, FVB/NJ, C3H/HeJ, DBA/2J, 129S2/SvPasOrlRj mice	[77]
	85	P0	10 d	C57BL/6 mice	[129, 181]
	85	P0	28 d	C57BL/6J, C57BL/6N mice	[78]
	85	P1	14 d	C57BL/6 mice	[182]
	85	P1	28 d	C57BL/6 mice	[119]
	85	P3	12 d	Nlrp3^−/− and WT mice	[106]
	90	Birth	7 d	SCID-mice	[128]
	90	Birth	14 d	Sprague-Dawley rats	[169]
	90	P1	10 d	Sprague-Dawley rats	[183]
	≥90	P3	10 d	Wistar rats	[148]
	95	Birth	14 d	Sprague-Dawley rats	[66]
	95	Birth	14 d	Sprague-Dawley rats	[65]
	95	Birth	14 d	rats	[64]
	95	P0	7 d	C57BL/6 and SPC hEC-SOD TG mice	[58]
	95	P1	6 d	Sprague-Dawley rats	[146]
	>97	<P2	3 d–15 d	Sprague-Dawley rats	[92]
	96-100	P0	8 d	Sprague-Dawley rats (male)	[63]
	100	P0	4 d	Sftpc-EGFP mice, Rat Scgb1a1-rtTA and (otet)7CMV-cre bitransgenic mice x mT/mG mice	[67]
	100	P2	9-10 d	Wistar rats	[122]
Brain and lung	80	Birth	7 d	Sprague-Dawley rats	[48]
	85	P1	10 d	C57BL/6J mice	[47]
	85	P1	14 d	Sprague-Dawley rats	[46]
	90	P0	14 d	Sprague-Dawley rats	[45]