Shear-Induced ITGB4 Promotes Endothelial Cell Inflammation and Atherosclerosis

<div>LSS upregulates ITGB4 expression <i>in vitro</i> and <i>in vivo.</i> (a) Heat map of the expression of integrin family members. (b, c) HUVECs were exposed to static conditions or LSS for 0-24 h. The content of ITGB4 was detected by (b) western blot and (c) immunofluorescence. (d) Enface staining of the ITGB4 content of the aortic arch (AA) and thoracic aorta (TA) in C57Bl/6 mice. Scale bar: 20 <i>μ</i>m. 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Shear-Induced ITGB4 Promotes Endothelial Cell Inflammation and Atherosclerosis 