Functional Evaluation of KEL as an Oncogenic Gene in the Progression of Acute Erythroleukemia

Figure 5

KEL promotes tumorigenesis in vivo. (a) Body weight of mice transplanted with PBS or K562 cells with different treatment. (b) WBC detection at weeks 5 and 7. (c) The tumor burden rate of all the mouse models. (d) Representative images of bioluminescence imaging of AEL mice after vail vein injection at week 6. (e) Immunohistochemistry analysis of ki67 in tumors from AEL mice. (f) ki67 positive ratio calculated and shown in histogram. (g) Kaplan-Meier curves of overall survival showing the difference between mice with low and high KEL levels.

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