Cholecystokinin Octapeptide Promotes ANP Secretion through Activation of NOX4–PGC-1α–PPARα/PPARγ Signaling in Isolated Beating Rat Atria

Figure 7

Effects of PPARα and PPARγ on CCK-8s-induced SOD and CAT expressions in isolated beating rat atria. (a) The protein expression levels of SOD, CAT, and GPX were detected by Western blot. (b–d) The statistics histograms of Western blot were expressed as band density normalized versus β-actin. (e–g) The bands of SOD and CAT and their statistics histograms. Cont: control; CCK-8s: sulfated CCK-8; Lo: Loxiglumid, an antagonist of CCK₁ receptor; YM: YM022, an antagonist of CCK₂ receptor; GW64: GW6471, an antagonist of PPARα; GW96: GW9662, an inhibitor of PPARγ. Data were expressed as . (a–g) . and vs. control group; ^### vs. CCK-8s group.

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