Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy

Figure 1

(a) ROS can dissociate the Nrf2/Keap1 complex in the cytoplasm; then, the Nrf2 translocates into the nucleus, acting on downstream antioxidant genes and alleviating OS damage. (b) ROS activates the NF-κB-mediated inflammatory signaling pathway, exacerbating cardiac OS damage. Meanwhile, activated Nrf2 causes a feedback inhibition of NF-κB pathway. (c) Upregulation of SIRT1 suppresses ROS generation and alleviates OS damage through antioxidant enzymes (GSH-Px and SOD) and PCG-1A/HO-1 pathway.