Resveratrol Treats UVB-Induced Photoaging by Anti-MMP Expression, through Anti-Inflammatory, Antioxidant, and Antiapoptotic Properties, and Treats Photoaging by Upregulating VEGF-B Expression

Figure 6

Effect of RES on inflammation-related indicators in the skin of UVB-induced photoaging Hacat cells and ICR mice. (a) Relative expression content of mRNA for IL-6 and TNF-α in photoaging Hacat cells using GADPH as an internal reference (). (b) Changes in IL-6 content in photoaging Hacat cells (). (c) Relative expression content of mRNA of IL-6 in the skin of photoaging ICR mice using GADPH as an internal reference (). (d) Changes in COX-2 protein levels in photoaging Hacat cells (). (e) Relative grey values of COX-2 protein in photoaging Hacat cells using GADPH as an internal reference.(f) Changes in P-ERK1/2, ERK1/2, P-P38MAPK, and P38MAPK protein levels in photoaging Hacat cells (). (g) Relative grey values of P-ERK1/2, ERK1/2, P-P38MAPK, and P38MAPK proteins using GADPH as an internal reference. (h) Changes in COX-2 protein levels in the skin of photoaging ICR mice (). (i) Relative grayscale values of COX-2 proteins using GADPH as an internal reference. (j) Changes in P-JNK, P-ERK1/2, and P-P38MAPK protein levels in the skin of photoaging ICR mice ().(k) Relative grey values of P-JNK, P-ERK1/2, and P-P38MAPK proteins in the skin of photoaging ICR mice using GADPH as an internal reference. , , , compared to control; #, ##, ###, compared to model. C: control group; U: model group; R20, R40: RES concentration of 20 and 40 μM drug-administered groups.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)